Cytotron - Wound Healing Application

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Post-traumatic multi-organ Regeneration using principles of RFQMR and non-invasive tissue engineering to induce inherent pluripotent stem cells in man

In 1987 it  was hypothesized that if an appropriate method can be developed to alter cellular Trans-Membrane Potential (TMP) in a controlled manner, most disorders that are  linked to specific protein de-regulation could be remedied. In 2003, 60 man-years of continuous research resulted in the development of the first prototype of  a therapeutic device called the CYTOTRON®  to effectively modulate TMP and engineer tissues and today more than 30 clinics are operational globally. An  international patent “A method for Tissue Regeneration and Degeneration in Humans and an Apparatus thereof” described this concept and today about 32 clinics are operational world-wide.

Current Concepts in Regenerative Medicine 21st Century revolve around the use of extrinsic sources of pluripotent stem cells.  These stem cell initiatives are driving pharma financed research for organ transplants by organogenesis and other biological applications like wound-and burn healing at very high costs. Consequently, the cost of these medical applications in humans, will also be priced exorbitantly.  Induced Pluripotent Stem cells made from mature fibroblasts that will avoid immunological rejection problems and overcome the need to use egg or fetal cells,  can be used to mature into cells needed by healthy donors years later, when the need arises. It is common to have umbilical tissue and cord blood stored as a natural contingency to drive these initiatives as they mature into modern stem cell therapies years later.

BACKGROUND

The natural process of cellular differentiation, de-differentiation and re-differentiation is lost in higher mammals like man, except for the natural regeneration of injured liver tissue. However, certain invertebrates and lower vertebrates like star fish, salamanders, lizards, etc. can regrow some body parts. By simulating this mechanism of tissue injury and repair, a small prototype unit was developed based on inherent principles of RF and MR to initiate and repair injured tissue in the traumatically amputated small digit of a human little toe as seen in the schematic presented below where an attempt was made to reverse a phenomenon larger mammals have lost to evolution. Manuscript in preparation

Application of RFQMR delivered remotely to repair the traumatic injury to underlying tissues, over a period of 28 days resulted in non-invasive regeneration of bone, muscle, skin, hair follicle and sensation.

Application of RFQMR delivered remotely to repair the traumatic injury to underlying tissues, over a period of 28 days resulted in non-invasive regeneration of bone, muscle, skin, hair follicle and sensation.

Cytotron’s platform technology for tissue regeneration is anticipated in:

  • the healing of diabetic neuropathy related peripheral amputation, wound / burn healing and regional organogenesis by stimulating inherent pluripotent stem cells without the need for extraneous sources of stem cells.

  • Potential to inherent induce pluripotent stem cells in the treatment of end-organ failures, once they develop certain metabolic diseases like diabetes or nephropathies.

  • Donor organogenesis and transplants could be enabled without encountering auto-rejection